Amiodarone-Induced Acute Liver Injury

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Amiodarone-Induced Liver Injury and Cirrhosis

We present a case report of an 80-year-old woman with volume overload thought initially to be secondary to heart failure, but determined to be amiodarone-induced acute and chronic liver injury leading to submassive necrosis and bridging fibrosis consistent with early cirrhosis. Her histopathology was uniquely absent of steatosis and phospholipidosis, which are commonly seen in AIC.

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Background Intravenous (IV) amiodarone may be associated with liver injury that may necessitate drug discontinuation. The prediction of amiodarone induced liver injury (AILI) and its severity may help careful patient monitoring or the choice of other measures alternative to amiodarone in high risk patients. Little is known regarding predictors of AILI. Objectives To address the predictors of ...

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ژورنال

عنوان ژورنال: Case Reports in Gastroenterology

سال: 2020

ISSN: 1662-0631

DOI: 10.1159/000506184